Magnesium Citrate
Commonly found in:
nuts (almonds, cashews, Brazilian nuts)
Supports nerve function, supports a healthy inflammatory response, and promotes healthy vascular reactivity. In clinical trials, daily supplementation reduced head discomfort frequency by over 40% compared to placebo4 8 9.
Vitamin B12
Commonly found in:
meat, eggs, dairy
Essential for nerve health. In clinical trials, supplementation reduced head discomfort frequency by 43% and decreased reliance on medications3 14 15.
Vitamin B2 (Riboflavin)
Commonly found in:
meat, fish
Vital for mitochondrial energy production. Daily high-dose riboflavin cut head discomfort days in half for 59% of patients, compared to only 15% with placebo6 10.
Coenzyme CQ10
Commonly found in:
Organ meat, soybeans, whole grain
Supports mitochondrial function. A 3-month study showed a 43% reduction in head discomfort frequency, with nearly half of participants cutting migraine days by 50%5 16.
Folate (Vitamin B9)
Commonly found in:
dark leafy green vegetables (spinach, kale)
Helps supports a healthy inflammatory response and lower homocysteine. In women with head discomfort, folate reduced attack frequency by 31% and lowered disability scores3 11 12 13.
Vitamin D3
Commonly found in:
Fatty Fish (salmon and sardines), egg yolk
Plays a role in immune and neurological health. In studies, 2,000 IU daily reduced head discomfort frequency by 35%, duration by 39%, severity by 25%, and lowered inflammatory markers2 17 18 19.
References
¹ Hopkins Medicine (2025), ² Ghorbani et al., 2020, ³ Nematgorgani et al., 2022, ⁴ Peikert et al., 1996, ⁵ Sandor et al., 2005, ⁶ Schoenen et al., 1998,
⁷ Biscetti et al., 2023, ⁸ Dominguez et al., 2025, ⁹ Barbagallo et al., 2021, 10 Mosegaard et al., 2020, ¹¹ Zhao et al., 2022, ¹² Kronenberg et al., 2008, ¹³ Li et al., 2016, 14 Green & Miller, 2022, 15 van de Lagemaat et al., 2019, 16 Testai et al., 2021, 17 Holick, 2017, 18 Ruggiero et al., 2025, 19 Ghorbani et al., 2020, 20 Rui et al., 2025
