The Science Behind Migra-Health
A multi-nutrient formula developed by a leading team of experts, scientists and physicians designed to help reduce the frequency and duration of head discomfort that puts life on hold.
Migra-Health™ was developed with neurologists and headache experts to target several biological pathways that are overactive in people who live with recurrent head discomfort. Research suggests that these episodes often involve a mix of mitochondrial “energy deficit” in brain cells, increased cortical excitability (nerves firing too easily), release of pain-signaling neuropeptides like CGRP, low-grade neuroinflammation, and, in some people, elevated homocysteine that can stress blood vessels. Migra-Health combines magnesium, riboflavin (B2), methylfolate (B9), methylcobalamin (B12), vitamin D3 and coenzyme Q10 in doses informed by clinical studies on each ingredient.
Magnesium helps calm over-excitable neurons by blocking NMDA receptors and supporting normal ion balance; deficiency has been linked to cortical spreading depression and higher CGRP levels, and supplementation has shown preventive benefits in people with migraine. Riboflavin and CoQ10 are central to mitochondrial energy production—both act as cofactors in the electron transport chain—so providing higher amounts appears to correct the energy shortfall seen in migraine brains and has reduced attack frequency and headache days in randomized trials using high-dose riboflavin (400 mg/day) and CoQ10 (typically 300 mg/day).
Vitamin D3 supports a healthy inflammatory response and may modulate CGRP and glutamate signaling; low vitamin D status has been associated with higher migraine prevalence, and trials using 2,000 IU/day have reported fewer headache days and lower CGRP levels in episodic migraineurs.
Folate and vitamin B12 work together to recycle homocysteine, an amino-acid byproduct that, when elevated, has been linked to migraine (especially migraine with aura) and vascular stress. By supporting normal homocysteine metabolism, these methylated B vitamins help maintain healthy endothelial (blood vessel) function and long-term brain health.
When you take Migra-Health daily, you are steadily supporting mitochondrial energy, calming over-reactive neural circuits, promoting a healthier inflammatory and CGRP profile, and protecting the vasculature that feeds your brain. Together, these mechanisms are designed to support fewer, more manageable head-discomfort days and a brain that can show up more consistently over time.
Scientific Advisory Board
Dr. David Dodick, MD, FAHS, FRCPC
Neurologist & Professor Emeritus, Mayo Clinic
A world-renowned neurologist specializing in headache medicine and brain health, Dr. Dodick has authored over 900 peer-reviewed publications and led numerous international research studies. He is passionate about advancing approaches to neurological care and helping people live longer, cognitively healthier lives.
Dr. Jessica Ailani, MD
Professor Clinical Neurology, Medstar Georgetown University Hospital
Jessica Ailani, MD, is a Professor of Clinical Neurology at MedStar Georgetown University Hospital and Director of the MedStar Georgetown Headache Center. She is a member of the board of directors and the Treasurer of the American Headache Society. She is Internationally renowned for her clinical expertise and research accomplishments. She has published many peer-reviewed papers, and was the lead author on a National Consensus statement on integrating new migraine treatments into clinical practice.
Dr. Brent Bauer, MD
Director of Integrative Medicine, Mayo Clinic
Dr. Bauer has spent over two decades at the forefront of evidence-based integrative health, exploring how natural therapies, nutrition, and lifestyle can optimize wellness. He brings his deep expertise to Minded’s mission of creating clean, effective, and holistic solutions for lifelong brain health.
Dr. Frank Porreca, PhD
Professor of Pharmacology, University of Arizona
Dr. Porreca is a globally recognized leader in the neuroscience of pain, with groundbreaking research in understanding how the brain processes discomfort and how natural mechanisms can be harnessed for relief. His work has paved the way for innovative, non-invasive solutions to chronic head pain and neurological sensitivity.
Migra-Health is a dietary supplement, not a drug. It is formulated based on evidence for individual ingredients. Always talk with your healthcare provider before starting any new supplement, especially if you use prescription medications or have medical conditions.
